Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
نویسندگان
چکیده
منابع مشابه
Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
BACKGROUND Ethyl pyruvate (EP) was recently identified as an experimental therapeutic agent in a wide variety of model systems for inflammation-mediated tissue and cellular injury. OBJECTIVE To evaluate the effect of ethyl EP on improving the survival in mice with LPS-induced acute lung injury (ALI). METHODS ALI was induced by administering lipopolysaccharide (LPS) intratracheally. The mice...
متن کاملEthyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis.
PURPOSE To investigate if the ethyl-pyruvate solution could reduce mortality in AP and/or diminish the acute lung injury. METHODS Forty male rats, weighing between 270 to 330 grams were operated. An experimental model of severe AP by injection of 0.1 ml/100g of 2.5% sodium taurocholate into the bilio-pancreatic duct was utilized. The rats were divided into two groups of ten animals each: CT -...
متن کاملAntecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a two-hit mouse model.
Acute kidney injury (AKI) contributes greatly to morbidity and mortality in critically ill adults and children. Patients with AKI who subsequently develop lung injury are known to suffer worse outcomes compared with patients with lung injury alone. Isolated experimental kidney ischemia alters distal lung water balance and capillary permeability, but the effects of such an aberration on subseque...
متن کاملAutotaxin and Endotoxin-Induced Acute Lung Injury
Acute Lung Injury (ALI) is a life-threatening, diffuse heterogeneous lung injury characterized by acute onset, pulmonary edema and respiratory failure. Lipopolysaccharide (LPS) is a common cause of both direct and indirect lung injury and when administered to a mouse induces a lung phenotype exhibiting some of the clinical characteristics of human ALI. Here, we report that LPS inhalation in mic...
متن کاملHypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury.
BACKGROUND Hypercapnic acidosis frequently occurs when patients with acute lung injury are initially ventilated with low tidal volume "protective" strategies. Hypercapnic acidosis per se, in the absence of any change in tidal volume or airway pressure, is protective when instituted before the onset of injury. However, the mechanisms by which hypercapnic acidosis confers this protection are inco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Respiratory Research
سال: 2009
ISSN: 1465-993X
DOI: 10.1186/1465-9921-10-91